The Position
In Roche'sPharmaceutical Research and Early Development organisation (pRED),we make transformative medicines for patients in order to tackle some of theworld's toughest unmet healthcare needs. At pRED, we are united by our missionto transform science into medicines. Together, we create a culture defined bycuriosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
The biomarker group within pRED Early Development Oncology is working on deciphering the complexity of human tumor-host biology by leveraging preclinical and clinical biomarker data for the oncology pipeline. Our goal is to increase the success rate of portfolio molecules by leveraging the understanding of the drug MoA and resistance mechanisms resulting in optimized patient enrichment early on in clinical development. We are seeking a highly motivated Biomarker and Experimental Medicine Leader to join the group and help lead the biomarker efforts for our pipeline molecules in the field of cancer immunotherapy and molecular targeted therapies.
Job mission
In this role, you will be leading and coordinating a matrix-team of multidisciplinary scientists. You will be responsible for the development, execution and oversight of preclinical and early clinical biomarker strategies for pRED oncology portfolio molecules and global biomarker related projects. You will work and align with internal experts within the Oncology Biomarker Group such as Pathologists, CDx Experts, Biomarker Scientists and Data Sourcing Experts.
In addition, you will closely collaborate with internal pRED stakeholders such as Medical Directors and Clinical Scientists, Pharmacologists, Bioinformaticians and Biostatisticians, Research Leaders, Regulatory and Operational Experts as well as with colleagues from Roche late stage biomarker and clinical development.
Your impact
You are accountable for all project biomarker deliverables. This includes the definition, implementation and testing of the project biomarker strategy to inform on dose/treatment schedule selection, PoM/PoC as well as safety assessments in pre-clinical and clinical trials.
Further, you will identify prospective and retrospective project specific patient enrichment as well as Companion Diagnostics development options to increase the probability for clinical success integrating pre-clinical, clinical as well as real world high and low dimensional data.
You lead multifunctional matrix teams and integrate technical expert input to develop and implement(pre-) clinical analytical concepts related to the proposed biomarker strategy.
You develop a biomarker plan, identify and prioritize state of the art technology platforms and key contributors. Furthermore, you will define the sampling strategy for the projects you are responsible for. The delivery of biomarker-specific sections of project-level documentation is up to your hands.
You are in charge of communicating biomarker concepts /data to internal and external stakeholders such as senior leadership, governance bodies, clinical investigators etc. (incl. preparation, coordination, review, presentation).
You identify and implement opportunities for forward and reverse translation to characterize disease (sub)populations, identify resistance and escape mechanisms and predict treatment responses of portfolio molecules.
Your profile
As a team player you integrate easily into a pro-active and inspiring global organization. You are able to prioritize your work in order to focus on individual goals as well as on team deliverables.
You can work as an individual contributor and you are an experienced matrix leader and decision maker with strong visionary, architect, catalyst & coaching leadership skills to influence and motivate teams.
You look back on at least 5 years of experience (beyond post-doctoral training) in drug development and translational research in either an academic and / or industry setting.
We can trust in your experience and understanding of diagnostic product development as well as clinical pharmacology.
You hold a PhD, MD or PhD/MD degree in a relevant scientific field e.g. immunology, pathology, molecular biology, cancer genetics, cancer biology, hematology, molecular oncology or bioinformatics with profound experience in cancer immunology, either in a research or clinical setting.
Data analysis and management are your strong points.
Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
Roche is an Equal Opportunity Employer.